Mouzaki (Greek: Μουζάκι, romanized: Mouzáki) is a town and a municipality in the northwestern part of the Karditsa regional unit, Greece. Mouzaki is located on the southwestern edge of the Thessalian plain, where the river Pamisos descends from the Agrafa mountains. It is 17 km southwest of Trikala and 24 km northwest of Karditsa. The Greek National Road 30 (Arta - Trikala - Karditsa - Volos) passes north of the town.
In 2020, Mouzaki was heavily affected by the medicane known as Cyclone Ianos. The town was flooded for several days.
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