Iisalmi ( EE-sahl-me; Finnish: [ˈiːsɑlmi]; Swedish: Idensalmi) is a town and municipality in the region of Northern Savonia in Finland. It is located 87 kilometres (54 mi) north of Kuopio and south of Kajaani. The municipality has a population of 20,493 (31 August 2024), which makes it the second largest of the five towns in Northern Savonia in population, only Kuopio being larger. It covers an area of 872.20 square kilometres (336.76 sq mi) of which 109.22 km2 (42.17 sq mi) is water. The population density is 26.86 inhabitants per square kilometre (69.6/sq mi). The municipality is unilingually Finnish.
In the 2010s, Iisalmi is known as an export industry town, as well as a significant study town in the region.